ESHRE 2025 in paris – my report with strategies and innovations in infertility treatment.

This conference was truly inspiring — practical, modern, and full of new data and solutions for improving IVF outcomes.

1. PPOS + AI — a simple protocol without antagonist injections

   PPOS is a modern alternative to classical stimulation.
   Instead of daily injections to prevent premature ovulation, progesterone tablets are used.

   Advantages:

• Fewer injections
• More convenient and comfortable
• A safe and effective protocol, especially in oocyte or embryo freezing programs.
  Suitable for women planning embryo transfer later or in complex clinical cases.

2. PERFORM – what is it and why is it important?

   PERFORM is a large European study that investigated how to correctly select hormone doses for ovarian stimulation in IVF.
   It studied a specific combination of two hormones: FSH and LH. It was found that this combination:

• helps retrieve more oocytes,
• improves embryo quality,
• increases chances of pregnancy.
  This protocol is especially effective for women with low ovarian reserve or over the age of 35.

4. Progesterone support of the luteal phase (LPS)

• Serum progesterone level (P) ≥ 9.2 ng/mL on the day of embryo transfer — OPR (ongoing pregnancy rate) was 53% with adequate progesterone vs 32% with lower levels.
• Recommendation: monitor progesterone levels before embryo transfer + personalize LPS in FET cycles (treat progesterone level below 9.2 ng/mL as the cut-off).

4. BMI and harmful habits

• BMI ≥ 25 → lower progesterone levels with the same LPS dose → reduced implantation rates.
• Smoking and alcohol → oxidative stress and decreased embryo quality.

5. Strategy for thin endometrium — when EMT < 7 mm

   ESHRE recommends:

• Optimize estrogen support (transdermal, oral);
• Add PRP or granulocyte colony-stimulating factor (G‑CSF) for intrauterine infusion (data still limited);
• Perform hysteroscopy in case of suspected synechiae and to rule out chronic endometritis.

6. Our presentation from Reprolife Clinic: “The impact of platelet-rich plasma on oocyte yield and blastocyst development in IVF patients undergoing DuoStim protocol”

   Main findings:

• Comparison before and after PRP in DuoStim (double stimulation in two phases of the menstrual cycle):
• Increased number of fertilized oocytes;
• Increased total number of blastocysts;
• Increased number of good-quality blastocysts;
• PRP application in DuoStim showed significant improvement in the second stimulation cycle.
  This presentation adds strong evidence for the effectiveness of intraovarian PRP in DuoStim protocols.

7. AI for predicting implantation and preeclampsia

The Carlos Simon Foundation received awards for their AI models for early prediction of implantation and preeclampsia — a new level of reducing uncertainty.

Practical takeaways:

• Pergoveris + personalization: r‑hFSH:LH ≥150 IU → more oocytes, higher effectiveness.
• PPOS + AI: reduces the number of injections during stimulation.
• LPS monitoring: progesterone ≥9.2 ng/mL before embryo transfer → individualized dosing.
• Thin endometrium: optimized estrogen + PRP/G‑CSF + hysteroscopy.
• PRP in DuoStim: improves maturity and quality of blastocysts.
  Lifestyle: BMI, harmful habits — critically important for success.

ESHRE 2025 is all about smart personalization in treatment, AI-powered decisions, innovations (like PRP), and supporting every couple. It’s not just a conference — it’s a testament to love for the profession and life.